![]() ![]() Although sore throat and throat irritation exist as a side effect in the summary of product characteristics, these side effects are reported in neither safety trials for adult upper limb spasticity nor case reports. ![]() These side effects are muscle weakness, dysphagia, skin rashes, flu-like symptoms, local injection site pain, asthenia, nasopharyngitis, urinary tract infections, dizziness, and epileptic seizures. However, several side effects related to spread of abobotulinum toxin A distant from the site of administration have been mentioned in the summary of product characteristics. Botulinum toxin A has been shown to be a safe and effective therapy for the treatment of upper limb spasticity after stroke. ![]() Botulinum toxin inhibits the release of acetylcholine from nerve terminals at the neuromuscular junction and weakens the muscle and, thus, decreases spasticity in this way. Botulinum toxin injections are usually applied as focal antispastic agents as the part of rehabilitation programs to improve active and passive function, to decrease pain related to passive mobilization and painful spasms, to improve hygiene, and to avoid contractures. ![]()
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